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|This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Meghanw27, Kkyann27, Stephanie Truong Group 27, Aajeng27. Peer reviewers: 3shalim26, Qinx26, Kran26, Danma26.|
Correction suggested in Mechanism of Action: THF is a precursor to the nucleotide thymidine (not thymine, which is a base). Also, cells are not starved for bases required in DNA replication, but for deoxyribose nucleotide, specifically thymidine.
Correction to picture: sulfonamides inhibit dihydropteroate synthase, not reductase. Can someone change this please? Axl 13:19, 15 Nov 2004 (UTC)
- Yep, thanks for pointing that out - I've corrected the error in the diagram. Techelf 06:15, 16 Nov 2004 (UTC)
- Thanks for fixing it. :-) Axl 11:13, 19 Nov 2004 (UTC)
Confused about the "Mechanism of action" section
Should the sentence starting "Folic acid is an essential precursor in the de novo synthesis..." start with "Tetrahydrofolic acid..." ??
If not, how is inhibition of tetrahydrofolic acid synthesis supposed to affect de novo synthesis of thymidine and uridine?
Or, if folic acid is an essential precursor of thymidine and uridine, the article doesn't make clear why inhibiting reduction of dihydrofolic acid to tetrahydrofolic acid inhibits tymidine and uridine synthesis.
- You're right, it was a bit unclear. Technically it was correct (since folate -> dihydrofolate -> tetrahydrofolate), but most people probably don't know that. I've clarified it in the article. -Techelf 08:55, 28 May 2006 (UTC)
format is messed up
Bactrim DS incorrectly redirects to this page. Regular Bactrim correctly is re-directed to the Trimethoprim/sulfamethoxazole page, but Bactrim DS (bactrim double strenghth) is re-directed to Trimethoprim. If I can figure out how to do it, I'm changing this. Shoeless Ho (talk) 18:53, 16 August 2012 (UTC)
Peer Edit Suggestions
Does this draft submission reflect a neutral point of view? (yes/no) - No, because the very last two sentences has the word “claims.” “Trimethoprim and sulfamethoxazole are commonly used in combination due to claimed synergistic effects, and reduced development of resistance.This benefit has been questioned.”
Are the points included verifiable with cited published material? (yes/no) - Not sure if every sentence under renal and hepatic impairment sentence needs to be cited. Only last sentence cited.
What recommendations can you provide your colleague for improvement of their draft? For this portion, please consider both the editor’s goals and focus of their edits along with Wikipedia’s principles and Wikipedia manual of style for medicine-related articles. (100 words max) - In GENERAL, article can be more concise and direct, and should be in lay language. E.g. Cultures and susceptibility tests should be carried out to determine the susceptibility of the bacteria causing the infection to trimethoprim - this sentence is convoluted and can be written more direct. Same with “The metabolism of trimethoprim consists of 10-20% mainly by the liver whereas the remainder is excreted unchanged in the urine.” - Instead of explaining of hyperkalemia, just say ”can cause high levels of potassium” - What does contraindications mean? megaloblastic anemia? - Renal & hepatic impairment. → the general public might not know what creatinine clearance is. - Use lay language instead of linking “hypersensitivity” and “megaloblastic anemia” under Contraindications, “disulfram” in pregnancy, etc… - Don’t need the numbers under spectrum of susceptibility since that can change depending on location (i.e different hospitals) - Sun sensitivity is a side effect in the intro but not on the side effect list below. - Grammar/ formating issues - Capitalize first word after bullet points in CI - Under rare side effects: don’t need to start every bullet with “Trimethoprim” since the entire article is about Trimethoprim. - Under common side effects: do not need to rewrite “common side effects include” since it is already labeled as common right above. Same goes with contraindications. Too repetitive. - “When trimethoprim used alone for…” is grammatically incorrect. Should be “When trimethoprim is used alone for…” - Best not to use apostrophes to be more professional: “therefore, it’s rarely used alone.”
Spectrum of susceptibility
The spectrum of susceptibility section used to have dose ranges, with the mysterious label "MIC" but at least giving a clue what the section was about. Now it is just a list of scientific names. Unless expanded the section is useless and should be removed. If "spectrum of susceptibility" is a term of art and the species names alone do mean something, the section name needs a link to say what the list means.